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Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5'-3' exoribonuclease) in the nucleoplasm.
Sato S, Ishikawa H, Yoshikawa H, Izumikawa K, Simpson RJ, Takahashi N. Sato S, et al. Nucleic Acids Res. 2015 Dec 2;43(21):10397-410. doi: 10.1093/nar/gkv1069. Epub 2015 Nov 3. Nucleic Acids Res. 2015. PMID: 26531822 Free PMC article.
Although ARF, p53, and HDM2 also participate in the regulation of ribosome biogenesis, the involvement of CARF in this process remains unexplored. In this study, we demonstrate that CARF associates with 5'-3' exoribonuclease 2 (XRN2), which play …
Although ARF, p53, and HDM2 also participate in the regulation of ribosome biogenesis, the involvement of CARF in this process remains unexp …
A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe.
Tucker JF, Ohle C, Schermann G, Bendrin K, Zhang W, Fischer T, Zhang K. Tucker JF, et al. PLoS Genet. 2016 Feb 18;12(2):e1005873. doi: 10.1371/journal.pgen.1005873. eCollection 2016 Feb. PLoS Genet. 2016. PMID: 26889830 Free PMC article.
In fission yeast, Schizosaccharomyces pombe, heterochromatin-associated gene silencing is known to be mediated by RNA processing pathways including RNA interference (RNAi) and a 3'-5' exoribonuclease complex, the exosome. Here, we report a new RNA-processing pathway …
In fission yeast, Schizosaccharomyces pombe, heterochromatin-associated gene silencing is known to be mediated by RNA processing pathways in …
XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition.
Patidar PL, Viera T, Morales JC, Singh N, Motea EA, Khandelwal M, Fattah FJ. Patidar PL, et al. Sci Rep. 2020 Aug 28;10(1):14253. doi: 10.1038/s41598-020-71203-7. Sci Rep. 2020. PMID: 32859985 Free PMC article.
Persistent R-loops (RNA-DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5'-3'-exoribonuclease 2 (XRN2) degrades RNA to resolve R-loops and promotes transcription termination. ...Thus, PARP …
Persistent R-loops (RNA-DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5'- …
XRN2 Autoregulation and Control of Polycistronic Gene Expresssion in Caenorhabditis elegans.
Miki TS, Carl SH, Stadler MB, Großhans H. Miki TS, et al. PLoS Genet. 2016 Sep 15;12(9):e1006313. doi: 10.1371/journal.pgen.1006313. eCollection 2016 Sep. PLoS Genet. 2016. PMID: 27631780 Free PMC article.
XRN2 is a conserved 5'3' exoribonuclease that complexes with proteins that contain XRN2-binding domains (XTBDs). In Caenorhabditis elegans (C. elegans), the XTBD-protein PAXT-1 stabilizes XRN2 to retain its activity. XRN2 activity …
XRN2 is a conserved 5'3' exoribonuclease that complexes with proteins that contain XRN2-binding domains ( …
Upregulation of XRN2 acts as an oncogene in oral squamous cell carcinoma and correlates with poor prognosis.
Liu JC, Gao L, Li SM, Zheng JJ, Li DG, Zhi KQ, Ren WH. Liu JC, et al. Pathol Res Pract. 2021 Mar;219:153355. doi: 10.1016/j.prp.2021.153355. Epub 2021 Jan 30. Pathol Res Pract. 2021. PMID: 33626405
BACKGROUD: The 5'-3' exoribonuclease 2 (XRN2) has been reported involved in several tumors. ...XRN2 could be a useful prognostic biomarker and a potential therapeutic target for OSCC....
BACKGROUD: The 5'-3' exoribonuclease 2 (XRN2) has been reported involved in several tumors. ...XRN2 …
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Richard P, Feng S, Tsai YL, Li W, Rinchetti P, Muhith U, Irizarry-Cole J, Stolz K, Sanz LA, Hartono S, Hoque M, Tadesse S, Seitz H, Lotti F, Hirano M, Chédin F, Tian B, Manley JL. Richard P, et al. Autophagy. 2021 Aug;17(8):1889-1906. doi: 10.1080/15548627.2020.1796292. Epub 2020 Aug 7. Autophagy. 2021. PMID: 32686621 Free PMC article.
SETX dominant mutations result in a juvenile form of amyotrophic lateral sclerosis (ALS) called ALS4, whereas recessive mutations are responsible for ataxia called ataxia with oculomotor apraxia type 2 (AOA2). How mutations in the same protein can lead to different phenoty …
SETX dominant mutations result in a juvenile form of amyotrophic lateral sclerosis (ALS) called ALS4, whereas recessive mutations are respon …
Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection.
Ternette N, Wright C, Kramer HB, Altun M, Kessler BM. Ternette N, et al. Virol J. 2011 Sep 20;8(1):442. doi: 10.1186/1743-422X-8-442. Virol J. 2011. PMID: 21933386 Free PMC article.
Synthesis of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) mRNAs were found to be highly induced upon RSV infection in a time dependent manner. Accordingly, IFIT3 protein levels accumulate …
Synthesis of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 ( …
Hepatitis C virus subverts liver-specific miR-122 to protect the viral genome from exoribonuclease Xrn2.
Sedano CD, Sarnow P. Sedano CD, et al. Cell Host Microbe. 2014 Aug 13;16(2):257-264. doi: 10.1016/j.chom.2014.07.006. Cell Host Microbe. 2014. PMID: 25121753 Free PMC article.
The abundant, liver-specific microRNA miR-122 forms extensive base-pairing interactions with the 5' noncoding region of the hepatitis C virus (HCV) RNA genome, protecting the viral RNA from degradation. We discovered that the 5'-3' exoribonuclease Xrn2 …
The abundant, liver-specific microRNA miR-122 forms extensive base-pairing interactions with the 5' noncoding region of the hepatitis C viru …
Molecular Basis of XRN2-Deficient Cancer Cell Sensitivity to Poly(ADP-ribose) Polymerase Inhibition.
Viera T, Abfalterer Q, Neal A, Trujillo R, Patidar PL. Viera T, et al. Cancers (Basel). 2024 Jan 30;16(3):595. doi: 10.3390/cancers16030595. Cancers (Basel). 2024. PMID: 38339346 Free PMC article.
The termination of defective RNA polymerase II (RNAPII) is one of the major sources of R-loop formation. 5'-3'-exoribonuclease 2 (XRN2) promotes genome-wide efficient RNAPII termination, and XRN2-deficient cells exhibit increased DNA dama …
The termination of defective RNA polymerase II (RNAPII) is one of the major sources of R-loop formation. 5'-3'-exoribonucle …
Structural and biochemical studies of the 5'3' exoribonuclease Xrn1.
Chang JH, Xiang S, Xiang K, Manley JL, Tong L. Chang JH, et al. Nat Struct Mol Biol. 2011 Mar;18(3):270-6. doi: 10.1038/nsmb.1984. Epub 2011 Feb 6. Nat Struct Mol Biol. 2011. PMID: 21297639 Free PMC article.
The 5'3' exoribonucleases (XRNs) have important functions in transcription, RNA metabolism and RNA interference. The structure of Rat1 (also known as Xrn2) showed that the two highly conserved regions of XRNs form a single, large domain that defines the active site of the …
The 5'3' exoribonucleases (XRNs) have important functions in transcription, RNA metabolism and RNA interference. The structure of Rat1 (also …
24 results